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. Author manuscript; available in PMC: 2011 Nov 1.
Published in final edited form as: Neuropsychopharmacology. 2011 Feb 16;36(6):1260–1274. doi: 10.1038/npp.2011.12

Figure 6.

Figure 6

Clozapine shares a common signaling pathway (Akt/GSK pathway) with the mGluR2/3 agonist in normal rat PFC. Acute intraperitoneal administration of LY379268 (0.3 and 3.0 mg/kg) or clozapine (5 mg/kg) similarly affects the expression of GSK-3β and Akt. (A and B) The total protein levels of GSK-3β in all drug-treated groups were stable, without significant changes (P > 0.05). In contrast, clozapine and both doses of LY379268 significantly increased the expression of GSK-3β Ser9 phosphorylation (P < 0.05). Moreover, Akt was significantly increased in response to treatment with LY379268 (3.0 mg/kg) or clozapine (P < 0.05) but was not altered by treatment with LY379268 at 0.3 mg/kg. The phosphorylation of was, however, differentially and significantly changed by LY379268 at 0.3 mg/kg (increased almost 2-fold, P = 0.010) and at 3.0 mg/kg (decreased, P = 0.007) and decreased but not significantly by clozapine treatment (P = 0.057).