Table 2.
Correlation of MRI indices with optical-coherence-tomography and visual-acuity measurements.
| FA | MD | λ ∥ | λ ⊥ | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ± | − | + | ± | − | + | ± | − | + | ± | − | + | |
| PRNFL thickness | 0.41 § | 0.45 § | 0.35 | −0.35 ‡ | −0.39 ‡ | −0.40 | −0.29 * | −0.30 * | −0.40 | −0.39 § | −0.42 § | −0.43 |
| TMV | 0.25 ‡ | 0.27 * | 0.35 | −0.26 * | −0.28 * | −0.44 | −0.24 * | −0.20 * | −0.47 | −0.25 * | −0.27 * | −0.45 * |
| 100% acuity | 0.29 ‡ | 0.17 | 0.54 ‡ | −0.15 | −0.09 | −0.29 | −0.07 | −0.07 | 0.17 | −0.20 * | −0.10 | −0.39 |
| 2.5% acuity | 0.19 * | 0.13 | 0.36 | −0.18 | −0.10 | −0.27 | −0.13 | −0.11 | −0.15 | −0.18 | −0.08 | −0.35 |
| 1.25% acuity | 0.13 | 0.13 | 0.10 | −0.21 | −0.14 | 0 | −0.14 | −0.21 | 0.10 | −0.16 | −0.20 | 0.05 |
Correlation coefficients derived from mixed-effects regression analysis, accounting for correlations between optic nerves in the same individuals. Statistical significance is as follows:
*
(p<0.01)
‡
(p<0.001)
§
(p<0.0001)
Prior optic neuritis status is denoted:
±
all optic nerves (197 nerves, 104 individuals)
−
no prior optic neuritis (158 nerves, 96 individuals)
+
prior optic neuritis (35 nerves, 32 individuals).
Abbreviations: FA, fractional anisotropy. MD, mean diffusivity. λ∥, parallel diffusivity. λ⊥,perpendicular diffusivity. PRNFL, peripapillary retinal nerve fiber layer. TMV, total macular volume.