Fig. 3.

Alphaherpesvirus egress in neurons. Herpeseviruses replicate their genome in the nucleus. After nuclear encapsidation, capsids are released to the cytoplasm where they undergo envelopment at TGN or endosomes. Enveloped viruses engage kinesin for transport down the axon. At the axon terminal, virions engage myosin V for transport across the cortical actin network for fusion at the plasma membrane and release into the synapse.