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. Author manuscript; available in PMC: 2011 Aug 23.
Published in final edited form as: J Neurosci. 2011 Feb 23;31(8):2959–2964. doi: 10.1523/JNEUROSCI.3381-10.2011

Figure 3.

Figure 3

Granule cell dispersion induced by intrahippocampal injection of kainic acid. Confocal maximum projections illustrating the location of the granule cell layer (GCL), inner molecular layer (IML) and outer two-thirds of the molecular layer (MML+OML) in a (a) control mouse, (b) 1wk-IHpKA mouse and (c) 2wk-IHpKA mouse. Note the greater numbers of ectopic granule cells in the inner (white arrows) and outer two-thirds (light blue arrows) of the dentate molecular layers in the ipsilateral hemisphere of a SE-2wk mouse. Scale bar = 30 μm. d-f: Examples of YFP-expressing dentate granule cells with recurrent basal dendrites (white arrowheads) from the ipsilateral hemisphere of KA-SE mice. Granule cells are located in the molecular layer of the dentate gyrus. The insets in (d-f) are optical sections through the granule cell soma showing the colocalization of YFP (d-i, e-i, f-i) and Prox1 (d-ii, e-ii, f-ii). Scale bar in e applies to d as well and = 20 μm. Scale bar for f = 20 μm.