. Author manuscript; available in PMC: 2011 Jul 7.

Published in final edited form as: ScientificWorldJournal. 2010 Jul 7;10:1386–1399. doi: 10.1100/tsw.2010.143

TABLE 2.

Altered Biosynthesis of Proresolving Mediators in Human Disease

Disease	Defect	Ref.
Severe asthma	Decreased LXA₄ in whole blood, sputum, and BALFs	[14,62,63,64]
	Increased CysLT to LXA₄ ratio in blood and BALF	[62,63]
Asthma exacerbation	Decreased PD1 levels in exhaled breath condensates	[97]
Aspirin-intolerant asthma	Decreased LXA₄ production from whole blood	[66]
Exercise-induced asthma	Decreased LXA₄ in plasma	[100]
Scleroderma lung disease	Decreased LXA₄ in BALFs	[67]
Cystic fibrosis	Decreased LXA₄ in BALFs	[101]