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. Author manuscript; available in PMC: 2011 Sep 16.
Published in final edited form as: J Neurosci. 2011 Mar 16;31(11):4251–4259. doi: 10.1523/JNEUROSCI.6195-10.2011

Figure 7. Quantitative PCR demonstrates a different gene expression profile in βgal-positive neurons from sensitized cocaine-challenged rats, as compared to βgal-negative neurons from the same rats, or all neurons from saline-challenged rats.

Figure 7

(a) mRNA levels for the immediate early genes arc, fosB, and nr4a3 are increased in βgal-positive neurons. (b) mRNA levels for the D1-type cell marker prodynorphin (pdyn) are increased in βgal-positive neurons, while the D2 receptor drd2 is decreased in βgal-positive neurons. (c) mRNA levels for the kinase that activates p38 MAPK (map2k6) are decreased in βgal-positive neurons, while mRNA levels for the phosphatase that inactivates p38 MAPK (mkp1 or dusp1) are increased in βgal-positive neurons. n=3 for every sample. See Table 3 for p values. * indicates p<0.05 versus Neun-positive neurons from saline-injected rats.† indicates p<0.05 versus βgal-negative neurons from cocaine-injected rats.