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. Author manuscript; available in PMC: 2011 Apr 6.
Published in final edited form as: J Neurosci. 2006 Apr 19;26(16):4166–4177. doi: 10.1523/JNEUROSCI.0176-06.2006

Figure 1.

Figure 1

t-LTP and t-LTD at L4-L2/3 synapses are sensitive to D-AP5 and BAPTA. A, Top left, Representative EPSPs before and after t-LTD induction. Top right, Representative EPSPs before and after t-LTP induction. Middle, Mean time course of t-LTP and t-LTD. Open circles, t-LTD; closed circles, t-LTP. Bottom, Mean Vm and input resistance to show stability of recordings. B, t-LTD and t-LTP are blocked by postsynaptic BAPTA (5 mM). C, Time course of blockade of NMDA currents by D-AP5 (50 μM). The arrow marks 5 min from the beginning of D-AP5 application. D, Mean effect of 5 min of D-AP5 application before pairing (open squares). Closed squares are interleaved controls. E, Five minute D-AP5 application blocks t-LTP but not t-LTD. The summary of the effect of 5 min of D-AP5 application before pairing on t-LTD and t-LTP is shown. Error bars are SEM. *p < 0.05.