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. Author manuscript; available in PMC: 2011 Apr 6.
Published in final edited form as: J Neurosci. 2006 Apr 19;26(16):4166–4177. doi: 10.1523/JNEUROSCI.0176-06.2006

Figure 5.

Figure 5

Cannabinoid dependence of t-LTD. A, AM251 (3 μM) completely blocks t-LTD. t-LTD in the presence of AM251 (open circles), DMSO alone (closed circles), and normal Ringer’s solution (open triangles). B, Mean effect of AM251, VDM-11 (10–20 μM), and RHC80267 (50 μM) on t-LTD with relevant vehicle controls. C, AM251 has no effect on t-LTP. t-LTP in the presence of AM251 (open squares) and ethanol vehicle alone (closed squares). Right, Mean effect of AM251 on t-LTP. D, Anandamide (AEA) wash-in with presynaptic stimulation induces long-lasting depression. Open circles show cells with anandamide (40 μM) and subsequent AM251 wash- nat0.1 and 30Hz. Closed circles are interleaved controls with presynaptic stimulation alone. E, Mean effect of anandamide wash-in at 30 and 0.1 Hz, with postsynaptic BAPTA (5 mM; 30 Hz), AM251 (3 μM; 0.1 Hz), and MPEP (10 μM; 0.1 Hz). *p < 0.05.