Skip to main content
. Author manuscript; available in PMC: 2011 Apr 4.
Published in final edited form as: World J Biol Chem. 2011 Jan 26;2(1):1–13. doi: 10.4331/wjbc.v2.i1.1

Figure 1. Model of the differentiation and migration of osteoclast precursor myeloid lineage progenitor cells and osteroblast precursor mesenchymal stem cells in response to S1P gradient.

Figure 1

Pre-osteoblast cells express S1P2 to repress it chemotaxis towards PDGF. After BMP2- induced differentiation of pre-osteoblasts to osteoblasts, S1P2 is down-regulated to resume the chemotaxis to PDGF. The migration of osteoclast precursor myeloid linage progenitor cells to blood system is mediated by the S1P1 receptor. During RANKL-induced osteoclast differentiation, S1P1 expression is suppessed to favor the local bone localization and bone remodeling.