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. Author manuscript; available in PMC: 2011 May 3.
Published in final edited form as: J Neurosci. 2010 Dec 8;30(49):16459–16468. doi: 10.1523/JNEUROSCI.3748-10.2010

Figure 6.

Figure 6

Chronic SNC80 and ARM390 both reduce δ receptor-mediated inhibition of Ca2+ channels in DRGs. The inhibitory effect of SNC80 (1 µm) on voltage-dependent Ca2+ channels was measured in medium-large DRG neurons. A, B, Exemplar currents from SNC80-responsive (A) or -nonresponsive (B) DRGs. (1, baseline depolarization; 2, SNC80-induced inhibition). Calibration: 10 ms, 20 mA on the x- and y-axes, respectively. C, SNC80 inhibited Ca2+ currents in ipsilateral DRGs from CFA (V, 33 ± 11%), but not naive (N, −0.13 ± 0.87%) animals. Both chronic SNC80 (S) and ARM390 (A) treatments reduced this effect to levels seen in naive DRGs (11.7 ± 5.3 and 0.12 ± 2.4%, respectively). Cumulative data from 6–14 cells are presented showing percentage SNC80 inhibition of Ca2+ currents; *p < 0.05, ***p < 0.001.