Table 3. Depression and Psychiatric Symptom Outcomes: Average Treatment Effects for Patients Receiving an Advanced Practice Psychiatric Nurse Intervention, by Dose, Versus Usual Care.

APRN dose	Period	Depression (PHQ-9)a			Psychiatric symptoms (CSI)b
		Effect (d)	95% CI	pc	Effect (d)	95% CI	pc
Low	Baseline to 3M	−2.35	−5.1, 0.4	.09	−1.50	−5.8, 2.8	.50
	3M to 6M	1.81	−0.6, 4.0	.14	0.73	−3.3, 4.8	.73
	6M to 12M	−0.69	−3.3, 1.9	.60	0.69	−3.5, 4.9	.75
	Baseline to 12M	−1.07	−4.2, 2.1	.50	−2.11	−7.4, 3.2	.44
Moderate	Baseline to 3M	−1.50	−4.2, 1.2	.27	−3.28	−7.6, 1.0	.14
	3M to 6M	2.39	0.2, 4.6	.03	0.49	−3.3, 4.3	.80
	6M to 12M	−1.90	−4.9, 1.1	.22	−2.23	−7.1, 2.6	.37
	Baseline to 12M	−0.40	−3.4, 2.6	.79	−4.40	−9.4, 0.6	.09
High	Baseline to 3M	−4.19	−6.4, −2.0	<.001	−0.74	−4.2, 2.7	.68
	3M to 6M	2.26	−0.9, 5.4	.16	−3.11	−8.5, 2.3	.26
	6M to 12M	−1.60	−5.1, 1.9	.36	−5.63	−11.2, −0.01	.05
	Baseline to 12M	−4.17	−6.7, −1.6	.00	−3.69	−8.1, 0.7	.10

Note: Negative effect values indicate a decrease in symptoms and improvement.

^aPatient Health Questionnaire

^bColorado Symptom Index

^cCompared with participants who received usual care