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. Author manuscript; available in PMC: 2008 Aug 26.
Published in final edited form as: J Neurosci. 2004 Jul 21;24(29):6621–6628. doi: 10.1523/JNEUROSCI.1474-04.2004

Figure 2.

Figure 2

cGMP potentiates On bipolar cell responses through a pathway involving phosphorylation by cGK. A, Results from cells dialyzed with KT5823 and cGMP (n =5) or cGMP alone (n = 12) are plotted over 15 min. Inclusion of KT5823 in the pipette abolished potentiation of responses to a 150 msec sim-flash and induced a depression. B, The cGK inhibitory peptide DT-3 (n = 10) prevented potentiation of cGMP dialyzed cells when included in the internal solution. C, Summary of the results shown in A and B. Data points at 14–15 min of recording were averaged and are plotted for each condition. *p < 0.001, significance compared with cGMP.