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. Author manuscript; available in PMC: 2011 Aug 23.
Published in final edited form as: J Neurosci. 2011 Jan 12;31(2):764–774. doi: 10.1523/JNEUROSCI.5052-10.2011

Figure 4.

Figure 4

Loss of HDAC3/NCoR interaction enhances long-term OLM and ORM formation but has no effect on short-term memory. A, Mice received subthreshold training (3 min) in an environment with two identical objects and received a retention test 90 min (B) or 24 h (C) later in which one object is moved to a new location. B, Subthreshold training did not result in significant short-term memory by either genotype when tested 90 min later (n = 11–13 per group). C, However, DADm mice showed a significant preference for the novel object location 24 h after training compared with wild types (n = 9–10 per group; **p < 0.005). D, Mice received subthreshold training (3 min) in an environment with two identical objects and received a retention test 24 h later in which one object is replaced with a novel one (ORM). Schematic describes methods for E. E, DADm mice showed a significant preference for the novel object itself 24 h after training compared with wild types (n = 12–18 per group; *p < 0.05).