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. Author manuscript; available in PMC: 2012 Apr 6.
Published in final edited form as: J Neurosci. 2011 Apr 13;31(15):5782–5791. doi: 10.1523/JNEUROSCI.5559-10.2011

Figure 4. In isolated taste buds, GABA interrupts communication between Receptor cells and Presynaptic cells.

Figure 4

Isolated taste bud were sequentially depolarized with KCl, stimulated with tastants and with ATP, in the absence or presence of 10 μM GABA. A, Traces show stimulus-evoked 5-HT release from Presynaptic cells within the taste bud (i.e., responses from a 5-HT biosensor apposed to the taste bud). All stimuli (arrows) elicit 5-HT release as shown previously (Huang et al., 2007). GABA has no effect on ATP-evoked 5-HT release. B, same taste bud, showing effects of GABA on taste-evoked 5-HT release. Here, Presynaptic cells are indirectly triggered to release 5-HT and GABA-mediated inhibition is consistent with GABA acting to reduce ATP release from Receptor cells, thereby interfering with cell-cell excitation of Presynaptic cells. C, summary of several experiments as those in A,B. Details of bars and analyses as in Figure 1.