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. Author manuscript; available in PMC: 2011 Oct 13.
Published in final edited form as: J Neurosci. 2011 Apr 13;31(15):5589–5595. doi: 10.1523/JNEUROSCI.6566-10.2011

Figure 3.

Figure 3

MitoQ, but not DPI, prevents Aβ-induced increases in mitochondrial superoxide. A) Treatment of hippocampal slices with Aβ1–42 (500 nM) for 60 minutes increased the MitoSOX fluorescent signal (Red) in area CA1 compared to control slices. DAPI staining is shown as blue. Pretreatment of slices with MitoQ (500 nM) blunted the Aβ-induced elevation in the MitoSOX fluorescent signal. In slices pretreated with DPI (10 nM), Aβ still caused increases in the MitoSOX fluorescent signal. B) Treatment of slices with a scrambled Aβ1–42 peptide (500 nM) for 60 minutes did not alter the MitoSOX fluorescent signal. Results are representative of three independent experiments. Scale bar, 50 μm.