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(A) Hypothermic response to the 5-HT1A/7 agonist 8-OH DPAT is normal in Hetero-KO mice (i) and their Controls (ii). (B) Hypothermic response to the 5-HT1A agonist 8-OH DPAT is normal in Adult-Hetero-KO mice (i) and their Controls (ii). Hypothermic response to the 5-HT1A agonist 8-OH DPAT is abolished in Auto-KO mice (i) and normal in their Controls (ii), (n=3–6 mice/group/dose). Values are mean ±SEM; ***p<0.001.
