Scheme 7.
a(i) AcCl, pyridine (ii) Br2, AcOH, 40 °C, 65% (2 steps) (iii) NEt3, CH2Cl2, 82% (iv) aq. NaOH, Br2, dioxane, 5–10 °C, 85% (v) 2N aq. Na2CO3, DME, PdCl2(PPh3)2, 83 °C, 51% (vi) PdCl2(PPh3)2, THF, reflux
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