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. Author manuscript; available in PMC: 2012 Aug 17.
Published in final edited form as: ACS Chem Neurosci. 2011 Aug 17;2(8):411–432. doi: 10.1021/cn2000266

Scheme 11.

Scheme 11

a(i) MeOH, SOCl2, reflux (ii) H2, Pd/C, THF, AcOH, 88% (2 steps) (iii) con. HCl, EtOH, BrCH(CHO)2, 18% (iv) aq. H2SO4, heat (v) EDC, HOBt, DMF, 50 °C (vi) H2NCH2CH2NH2, aq. HCl, reflux, 70% (vii) Et3N·HCO2H, MeCN, 99%