Scheme 3.
a(i) NEt3, MeMgBr, PhMe, THF, 0 °C, 46% (ii) (R)-1-methyl-3,3-diphenylhexahydropyrrolo[1,2-c][1,3,2]oxazaborole, BH3·SMe2, PhMe, THF, 0 °C, 84% (iii) NEt3, MsCl, CH2Cl2 (iv) DIEA, DMSO, 90 °C, 60% (v) MeN=C=S, H2O, NaOH, 50 °C
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