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mGlu5 potency in the quinazoline series
| Entry | R1 | R2 | mGlu5 IC50 (nM) |
|---|---|---|---|
| 219 | Br | Cl | 256 |
| 220 | Br | H | >10,000 |
| 221 | Br | F | 1970 |
| 222 | Br | Br | 174 |
| 223 | Br | Me | 246 |
| 224 | Br | OMe | >10,000 |
| 225 | Cl | Cl | 130 |
| 226 | F | Cl | 311 |
| 227 | NO2 | Cl | 274 |
| 228 | OMe | Cl | 1510 |
| 229 | Cl | Br | 124 |
| 230 | F | Br | 96 |
| 231 | F | Me | 1350 |
| 232 | F | CF3 | >10,000 |
| 233 | F | CN | 1370 |
| 234 | F | OMe | >10,000 |
