Table II.
Average daily level of celecoxib, atorvastatin, and their metabolites in serum from SCID mice treated with celecoxib or atorvastatin alone or in combination.
| Serum concentration (ng/ml) |
|||||||
|---|---|---|---|---|---|---|---|
| Treatment | Atorvastatin | p-Hydroxy-atorvastatin | o-Hydroxy-atorvastatin | Celecoxib | Hydroxy-celecoxib | Carboxy-celecoxib | |
| Atorvastatin | 6.12±2.26 | 6.28±2.44 | 22.6±6.9 | - | - | - | |
| Celecoxib | - | - | - | 1090.4±127.9 | 234.6±26.8 | 331.1±58.4 | |
| Atorvastatin + celecoxib | 0.45±0.30 | 2.03±1.99 | 10.3±2.5 | 963.2±69.8 | 274.8±15.8 | 323.9±52.4 | |
Male SCID mice (10/group) were fed AIN76A diet containing 0.05% celecoxib, 0.02% atorvastatin, or 0.05% celecoxib+0.02% atorvastatin for two weeks. Serum samples were collected at 7 am (5 mice) and 7 pm (5 mice) on the last day of the experiment and analyzed for the levels of celecoxib, atorvastatin, and their metabolites. Since large differences in drug levels at 7 am and 7 pm were not observed, we combined the data from all animals from each group. Values for the mean ± S.E from 10 animals in each group are shown.