Skip to main content
. Author manuscript; available in PMC: 2011 Aug 4.
Published in final edited form as: Front Immunol. 2011 May 10;2(15):00015. doi: 10.3389/fimmu.2011.00015

FIGURE 1. Thymic lymphopenia and impaired T cell development in lig4R/R and rag1S/S mice.

FIGURE 1

(A) Total thymic cellularity from 4 to 5-weeks-old mice shows severe lymphopenia in lig4R/R and rag1S/S mice as compared to WT littermate controls. (B) Thymuses from 4 to 5-weeks-old mice were stained with anti-CD4 and anti-CD8 antibodies and the absolute numbers of live thymocytes at different stages of differentiation are shown in the bar charts (DN, double negative; DP, double positive). (C) Distribution of CD4−CD8− DN thymocytes at various stages of differentiation (DN1–DN4). Mean values ± SE are shown. At least six mice per group were analyzed.