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. Author manuscript; available in PMC: 2011 Dec 29.
Published in final edited form as: EJNMMI Res. 2011 Jun 7;1(1):1. doi: 10.1186/2191-219X-1-1

Table 1.

In vitro analysis of panitumumab F(ab’)2 conjugated with CHX-A”-DTPA

Analysis Chelate:mAb Ratio (molar excess)
Panitumumab F(ab’)2 HuM195 F(ab’)2
0 5X 10X 20X 10X
IC50 (nM) 0.5 0.6 0.7 0.7 0
Specific Activity (mCi/mg) --- 1.9 14.8 2.9 9.4
Labeling Yield (%) --- 13.9 49.4 24.4 50
Chelate:Protein Ratio --- 2.9 1.7 5.6 0.6
% Binding --- 59.5 59.4 54.7 1.8