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. Author manuscript; available in PMC: 2012 Feb 9.
Published in final edited form as: J Neurosci. 2008 Sep 24;28(39):9840–9849. doi: 10.1523/JNEUROSCI.1713-08.2008

Figure 6.

Figure 6

Bilateral subthalamic nucleus (STN) lesions did not alter ethanol withdrawal severity. (a) Schematic of histological sections depicting the extent of confirmed STN lesions (only one side is shown). Black shaded areas represent the minimal lesion area, and the hatched areas represent more extensive lesions observed in some animals. (b) Bilateral STN-lesioned and sham-lesioned D2 mice were scored for baseline handling-induced convulsions (HICs) immediately before administration of 4 g/kg ethanol (the arrow marks ethanol injection at time 0), and hourly between 2 and 12 hr post-ethanol administration. Data represent the mean raw scores ± SEM for baseline and post-ethanol HICs. Although the data suggest the possibility of a shift in the withdrawal time-course in STN-lesioned animals, statistical analyses of these data did not detect a significant difference at any time point, or in the overall time course. Inset: Bilateral STN lesions did not reduce ethanol withdrawal scores calculated as area under the withdrawal curve (AUC), as compared to the sham-lesioned group (p=0.6). Abbreviations: cc, corpus callosum.