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. Author manuscript; available in PMC: 2011 Dec 1.
Published in final edited form as: J Neurosci. 2011 Jun 1;31(22):7991–8000. doi: 10.1523/JNEUROSCI.6650-10.2011

Figure 4.

Figure 4

Flash response families of dark adapted control cones (A) and GCAPs−/− cones (B) from transretinal recordings. Cone responses were evoked by a series of 500-nm test flashes (10 ms in duration) with intensities (photons μm−2) 36, 1.2 × 102, 3.9 × 102, 1.1 × 103, and 3.6 × 103. The largest response in each case was triggered by unattenuated white flash. (C) Fractional single photon responses of control (black) and GCAPs−/− (gray) cones. Error bars show SEM. The cone collecting area was estimated to be 0.12 μm2 (see Eqn. (6) and Materials and Methods for details). (D) Intensity-response relations of cone transretinal responses to estimate sensitivity in control (closed circles) and GCAPs−/−(open circles) retinas. The solid curves represent the corresponding intensity-response functions (Eqn. (1)) with Io of 2,180 photons μm−2 and 918 photons μm−2, respectively. Error bars show SEM.