Skip to main content
. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: ACS Med Chem Lett. 2011;2(8):592–596. doi: 10.1021/ml2000824

Figure 1.

Figure 1

Role of DDAH and DDAH inhibitors. A) NO Synthase isoforms convert arginine (1) to citrulline (2) and NO. Dimethylarginine (3) inhibits all isoforms of NO synthase, and is catabolized to (2) and dimethylamine by DDAH. B) Structures of selected substrate-based DDAH inhibitors. (4): 4124W; (5): L-257; (6): N5-(1-iminopentyl)-l-ornithine; (7): N5-(1-iminobut-3-enyl)-l-ornithine; (8): 2-chloroacetamidine; (9): N-but-3-ynyl-2-chloroacetamidine.