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. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: J Bone Miner Res. 2011 Oct;26(10):2523–2536. doi: 10.1002/jbmr.450

Fig. 2.

Fig. 2

Lower tibia and femur trabecular bone volume in 12-week-old male KO mice. (A) The tibiae of 4, 8 and 12 week-old male WT and KO mice were analyzed by microCT analysis. Trabecular bone volume (BV/TV), trabecular number (Tb.N), trabecular thickness (Tb.Th), connectivity-density (Conn-Dens), and trabecular separation (Tb.Sp) were determined. (B) Tibia cortical bone analysis of 12 week-old males revealed that KO mice had slightly increased the endosteal perimeter. Cortical cross sectional area (Cort. CSA), cortical thickness (Cort. Th), periosteal perimeter (Perios. perim) and endosteal perimeter (Endos. perim) were determined. (C) Static bone histomorphometric analysis demonstrated reduced femoral, but not spine, trabecular bone volume in 12-week-old KO male mice. (D) Representative tibiae from WT and KO mice stained with H&E/orange G. (*p ≤ 0.05; **p ≤ 0.01)