Table 2.
Evolutionary rates estimated assuming the strict molecular clock and the uncorrelated lognormal (UCLD) relaxed clock. The difference between the mean rate and the weighted mean rate is explained in the main text. The WH-C HBeAg+ve data set contained insufficient information to estimate an evolutionary rate under the relaxed clock, and these results are not reported here.
| Data Set | Antigen state | Strict Clock | UCLD Relaxed Clock | UCLD Relaxed Clock | |||
|---|---|---|---|---|---|---|---|
| Mean | 95% HPD | UCLD Mean | 95% HPD | Weighted Mean | 95% HPD | ||
| AH-A | HBeAg+ve | 6.01E-04 | 4.07E-04–7.83E-04 | 8.60E-04 | 4.34E-04–1.43E-03 | 8.04E-04 | 4.41E-04–1.26E-03 |
| AH-C | HBeAg+ve and -ve | 1.23E-04 | 2.81E-05–2.12E-04 | 2.00E-04 | 5.41E-05–3.61E-04 | 1.88E-04 | 5.09E-05–3.34E-04 |
| AH-D | HBeAg+ve and -ve | 1.01E-04 | 4.57E-05–1.53E-04 | 1.21E-04 | 1.83E-05–2.27E-04 | 9.39E-05 | 1.87E-05–1.77E-04 |
| AH-E | HBeAg+ve | 1.94E-04 | 7.98E-06–3.75E-04 | 9.29E-04 | 1.81E-05–2.018E-03 | 6.97E-04 | 1.41E-04–1.28E-03 |
| AH-F | HBeAg+ve and -ve | 5.29E-04 | 3.49E-04–6.85E-04 | 1.11E-03 | 5.18E-04–1.76E-03 | 8.39E-04 | 4.44E-04–1.20E-03 |
| AH-H | HBeAg+ve | 4.39E-05 | 3.97E-08–1.11E-04 | 2.88E-04 | 6.48E-07–6.67E-04 | 1.75E-04 | 3.77E-06–3.54E-04 |
| WH-BC | HBeAg-ve | 9.55E-05 | 4.80E-05–1.52E-04 | 1.12E-04 | 1.40E-07–2.21E-04 | 9.63E-05 | 9.31E-06–1.80E-04 |
| WH-C | HBeAg+ve and -ve | 1.15E-04 | 3.09E-05–2.13E-04 | - | - | ||
| WH-D | HBeAg+ve and -ve | 1.36E-04 | 9.40E-05–1.80E-04 | 1.17E-04 | 3.49E-05–2.08E-04 | 5.78E-05 | 1.08E-05–1.16E-04 |