Table 2.

Genes in the ESP Whose Expression was Significantly Changed by Estradiol (5 nM) or luteolin (17.5 μM) Treatment of MCF-7 Cells for 5 Hours.

Gene	Estradiol Regulated Genes	Fold Change	Entrez Gene
CREBBP	CREB binding protein (Rubinstein-Taybi syndrome)	−1.57	1387
EP300	E1A binding protein p300	−1.89	2033
ESR1	estrogen receptor 1	1.75	2099
GTF2H2^a	general transcription factor IIH, polypeptide 2, 44kDa	1.68	2966
NCOA3^a	nuclear receptor coactivator 3	−1.65	8202
NCOR2	nuclear receptor co-repressor 2	1.76	9612
PGR	progesterone receptor	2.34	5241
POLR2J2	DNA directed RNA polymerase II polypeptide J-related gene	−1.69	246721
SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	−1.45	6597
TRRAP	transformation/transcription domain-associated protein	−1.68	8295

Gene	Luteolin Regulated Genes	Fold Change	Entrez Gene
CTBP2	C-terminal binding protein 2	−1.43	1488
DDX5	DEAD (Asp-Glu-Ala-Asp) box polypeptide 5	−1.29	1655
GRB2	growth factor receptor-bound protein 2	−1.55	2885
GTF2H2^a	general transcription factor IIH, polypeptide 2, 44kDa	−1.43	2966
HNRPD	heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)	−2.26	3184
NCOA3^a	nuclear receptor coactivator 3	−1.84	8202
NCOR1	nuclear receptor co-repressor 1	−1.52	9611
NRAS	neuroblastoma RAS viral (v-ras) oncogene homolog	−1.36	4893
NRIP1	nuclear receptor interacting protein 1	−1.35	8204
PCK2	phosphoenolpyruvate carboxykinase 2 (mitochondrial)	−1.65	5106
POLR2A	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	−1.58	5430
TAF5L	TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa	1.48	27097
TAF6L	TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa	1.9	10629
TAF9	TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa	1.42	6880

Modulated by both Estradiol and Luteolin.