Table 3.

Genes in the CCP Whose Expression was Significantly Changed by Estradiol (5 nM) or Luteolin (17.5 μM) Treatment of MCF-7 Cells for 5 Hr

Gene	Estradiol Regulated Genes	Fold Change	Entrez Gene
CDC2^a	Cell division cycle 2, G1 to S and G2 to M	1.38	983
CDC20^a	CDC20 cell division cycle 20 homolog (S. cerevisiae)	−1.45	991
CDC25B	Cell division cycle 25B	−1.21	994
CDKN1B	Cyclin-dependent kinase inhibitor 1B (p27, Kip1)	−1.39	1027
GSK3b^a	Glycogen synthase kinase 3 beta	−1.44	2932
MAD2L1	MAD2 mitotic arrest deficient-like 1 (yeast)	1.75	4085
PCNA^a	Proliferating cell nuclear antigen	1.23	5111
PRKDC	Protein kinase, DNA-activated, catalytic polypeptide	−1.64	5591

Gene	Luteolin Regulated Genes
ASK	Activator of S phase kinase	1.43	10926
CCNA2	Cyclin A2	−1.45	890
CDC2^a	Cell division cycle 2, G1 to S and G2 to M	−1.27	983
CDC20^a	CDC20 cell division cycle 20 homolog	−1.5	991
CKDN1A	Cyclin-dependent kinase inhibitor 1A (p21)	1.67	1026
GSK3b^a	Glycogen synthase kinase 3 beta	−2.27	2932
PCNA^a	Proliferating cell nuclear antigen	−1.35	5111
PLK1	Polo-Like kinase 1	−1.66	5347
PTTG1	Pituitary tumor-transforming 1	−1.29	9232

Modulated by both Estradiol and Luteolin.