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. Author manuscript; available in PMC: 2011 Jul 12.
Published in final edited form as: Am J Cancer Res. 2011 Apr 1;1(4):432–445.

Figure 1.

Figure 1

Activation of K-ras leads to quick death of mice. A) Schematic of LSL-K-rasG12D locus. K-rasG12D with an upstream LoxP-STOP-LoxP cassette that can be excised by Cre recombinase. P1, P2 and P3, primers for genotyping. B) Genotyping products, before and 15 days after TAM treatment. 500 bp LSL cassette, 625 bp wild-type and 650 bp recombined fragments. TAM-induced activation of K-ras decreases survival of mice. C) Kaplan-Meier curve of control Ubc9 CreER mice and LSL-K-rasG12D/+ Ubc9 Cre ER mice after TAM feeding. Mice with K-ras activation had D) decreased body weights and E) decreased random blood glucose levels. F) Tumor in stomach of K-ras Ubc9 Cre-ER mice.