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Activation of K-ras causes hyperplasia of squamous epithelium and glandular epithelium within 15 days after TAM treatment. A) Control and B) K-rasG12D/+ H and E staining of gastric squamous epithelium. C) Control and D) KrasG12D/+ H and E staining of glandular epithelium. E) Glandular stomach in KrasG12D/+ mice in higher magnification (100X). F) Cross section of tumor in KrasG12D/+ mice.
