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. Author manuscript; available in PMC: 2011 Jul 25.
Published in final edited form as: Am J Cancer Res. 2011;1(2):155–167.

Figure 5.

Figure 5

Histological analysis of brain tumors arising in Nestin-TVA mice injected with viruses expressing KRas, Tet-off and TRE-Akt. H&E stained 5 μm brain histology sections from: A. a typical glioma in the brain of an untreated 24 days old mouse; B. a tumor from a mouse treated with doxycycline for 24 hours; C. a resistant tumor from a 57 day old mouse treated with doxycycline for 36 days (corresponds to the MRI shown in Figure 4C); D. a relapsed tumor from a 122 day old mouse 11 days after doxycycline withdrawal; E. a relapsed tumor from a 141 day old mouse 30 days after doxycycline withdrawal. F–J. IHC for the HA epitope tag on virally delivered Akt and hematoxylin counterstain corresponding to the tumors shown in (A–E). Scale bar represents 200 μm.