. Author manuscript; available in PMC: 2012 Aug 11.

Published in final edited form as: ACS Med Chem Lett. 2011 Aug 11;2(8):620–625. doi: 10.1021/ml200100t

Table 1.

Binding Affinities at the D₁-like, D₂-like, and D₃ Receptors in Binding Assays Using Rat Brain. Binding affinities for all the compounds in this Table were evaluated under the same assay conditions.

	K_i ± SEM (nM)			Selectivity
ligand	D₃ ([³H]-R(+)-7-OH-DPAT)	D₂-like [³H]Spiperone	D₁-like [³H]SCH23390	D₂-like/D₃	D₁-like/D₃
1	0.45±0.034	39± 4	>10,000	87	>10,000
11	0.80 ± 0.05	92 ± 9	>5,000	115	>5,000
12	1.6±0.25	1,628±234	11,557±996	1,039	7,373
13	0.93±0.094	3,549±421	14,057±1,095	3,816	15,115
14	0.41±0.038	584±72	6,125±271	1,416	14,848
15	0.35±0.019	564±52	3,058±198	1,627	8,822
16	0.40±0.087	725±45	1,616±167	1,827	4,074
17	0.50±0.080	2,568±302	10,127±1,002	5,136	20,254