Table 2.

Comparison of Calyx Proteins to Proteins in Nodes of Ranvier and Initial Segments

Calyx Domain	Protein Class	Protein Family	Isoform	Other Localization
1 Inner face/ postsynaptic	KV channel	M-like	KCNQ2	AIS1,2, nodes1
			KCNQ4	hair cells3, arterial smooth muscle4
			KCNQ5	brain, sympathetic ganglia5; vestibular type I hair cells3
		Dendrotoxin-sensitive	KV1.1, KV1.2	AIS2, juxtaparanode6,7
	NaV channel	NaV1	pan-NaV	AIS2, nodes6,7
		TTX-insensitive	NaV1.5	cardiac muscle8, embryonic DRG neurons9, vestibular hair cells 10
	CAM	KV channel-associated	Caspr1	paranode6,7
			contactin	paranode6,7
	ECM	NaV channel-associated	tenascin-C	hippocampal synapses11; vestibular type I hair cells12
	Scaffolding protein	NaV channel-associated	pan-dystrophin	nodes13, neuromuscular junctions14
2 Apex	KV channel	Ether-a-go-go-related (Erg)	Erg1	cardiac cells15, vestibular hair cells16
			Erg2
	CAM	KV channel-associated	Caspr2	AIS2, juxtaparanode6,7
	Scaffolding protein	NaV channel-associated	βIV spectrin	nodes13
3 Outer face/ initial segment	KV channel	M-like K channel	KCNQ3	AIS1, nodes1
	NaV channel	NaV1	pan-NaV	AIS1, nodes1
	Scaffolding protein	KV channel-associated	AnkyrinB	paranodes17
		NaV channel-associated	pan-dystrophin	nodes13, neuromuscular junctions14
4 Heminode	KV channel	M-like K channel	KCNQ3	AIS2, nodes1
			KCNQ4	hair cells3, arterial smooth muscle4
	NaV channel	NaV1	pan-NaV	AIS2, nodes6,7
		TTX-sensitive	NaV1.6	AIS2, nodes 18,19,20
		TTX-insensitive	NaV1.5	cardiac muscle7, embryonic DRG neurons8, vestibular hair cells 9
	Scaffolding protein	NaV channel-associated	βIV spectrin	AIS2, nodes19,20
			NF186	AIS2, nodes7
			ezrin	nodes13,18
			pan-dystrophin	nodes13, neuromuscular junctions 14
			ankyrinG	nodes1,6,7
Paraheminode	CAM	KV channel-associated	contactin	paranodes6,7
			Caspr1	paranodes6,7
	Scaffolding protein	KV channel	ankyrinB	paranodes17
Juxtaparaheminode	KV channel	Dendrotoxin	KV1.1, KV1.2	juxtaparanodes6,7
	CAM	KV channel	Caspr2	juxtaparanodes6,7
Axon	Structural protein of myelin		myelin basic protein	Internodes6

Abbreviations: AIS, axon initial segment; CAM, cell adhesion molecule; DRG, dorsal root ganglion; ECM, extracellular matrix protein; TTX, tetrodotoxin.

^*Table 2 References:

¹Bennett and Healy (2009), Cooper (2011);

²Hedstrom et al. (2007), Ogawa and Rasband (2008);

³Kharkovets et al. (2000, 2006);

⁴Ng et al. (2011);

⁵Schroeder et al. (2000), Tzingounis et al. (2010);

⁶Arroyo and Scherer (2000);

⁷Peles and Salzer (2000);

⁸Abriel and Kass (2005);

⁹Rush et al. (2007);

¹⁰Wooltorton et al. (2007);

¹¹Dityatev and Schachner (2006), Ullian and Dityatev (2006), Dityatev et al. (2010);

¹²Swartz and Santi (1999), Warchol and Speck (2007);

¹³Occhi et al. (2005);

¹⁴Pilgram et al. (2010);

¹⁵Schwarz and Bauer (2004);

¹⁶Hurley et al. (2006);

¹⁷Ogawa et al. (2006);

¹⁸Leterrier et al. (2011);

¹⁹Salzer (2003);

²⁰Salzer et al. (2008)