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. Author manuscript; available in PMC: 2012 Jan 20.
Published in final edited form as: J Neurosci. 2011 Jul 20;31(29):10579–10592. doi: 10.1523/JNEUROSCI.1592-11.2011

Fig. 2. Disynaptic Inhibition Determines Synaptic Summation of Excitatory Inputs in the DCN.

Fig. 2

A1. Two-pathway experiment diagram. A2. Example of subthreshold EPSP/IPSP evoked by PF stimulation. B. Two independent PF (modulatory) inputs (the first one always showing EPSP-IPSP sequence as shown in A2) were stimulated either simultaneously (Δt=0), or 1, 3 and 5 ms apart. Stimuli were adjusted to produce an action potential upon synchronous stimulation in ~ 50% of trials (10 repetitions are shown for each time interval). C. The average spike probability fell steeply when the two stimuli were not delivered synchronously (Δt >0). The probability for each cell was normalized by the probability obtained for Δt=0. Blocking glycinergic transmission with strychnine (500 nM) abolished the disynaptic IPSP (inset). Blockade of disynaptic inhibition widened the timing window for EPSP summation. Timing window for control is in black and timing window after strychnine is in gray. Data are means from 5–9 cells per point. All means are reported ± SEM