Skip to main content
. Author manuscript; available in PMC: 2012 Sep 23.
Published in final edited form as: J Neurosci. 2011 Aug 3;31(31):11396–11403. doi: 10.1523/JNEUROSCI.1393-11.2011

Figure 2.

Figure 2

Effects of intra-VTA injections of CRF-R1 receptor antagonists on reinstatement by intra-VTA CRF delivery and footshock stress in LgA rats. Data represent the effects of bilateral injections of antalarmin (500 ng/side; 2A; n=7) or CP-376395 (500 ng/side; 2B; n=6) or vehicle on reinstatement by bilateral intra-VTA delivery of CRF (500 ng/side) and the effects of bilateral injections of antalarmin (500 ng/side) on reinstatement (responses/2-h session ± S.E.) by electric footshock (EFS; 2C; n=6). In all cases, significant reinstatement was observed in rats pretreated with vehicle (*P<0.05 vs. Ext) but not CRF-R1 receptor antagonists and responding during reinstatement was significantly lower following CRF-R1 receptor antagonists compared to vehicle (#P<0.05 vs. Veh).