Skip to main content
. Author manuscript; available in PMC: 2011 Sep 7.
Published in final edited form as: Int J Oral Sci. 2010 Sep;2(3):117–126. doi: 10.4248/IJOS10042

Figure 1. Branching morphogenesis of submandibular glands (SMG) in vivo and in ex vivo culture.

Figure 1

Top panel: Mouse SMG isolated from embryonic day 12 (E12) through E15 illustrate the formation of a highly branched structure from a single epithelial bud. Bottom panel: The pattern of in vivo branching morphogenesis can be closely reproduced by ex vivo culture of an E12 SMG. M denotes mesenchyme, E denotes epithelium, and empty and filled arrowheads show examples of early and deepening clefts, respectively.