. Author manuscript; available in PMC: 2013 May 1.

Published in final edited form as: Influenza Other Respir Viruses. 2011 Sep 21;6(3):167–175. doi: 10.1111/j.1750-2659.2011.00288.x

Table 3.

Cost, Effectiveness, and Incremental cost-effectiveness ratio (ICER) of Switching from Annual to Universal Vaccine when Universal Vaccine Provides 10 years of Protection (50% Symptomatic Influenza Rate)

		Annual Vaccine Compliance	Vaccination Strategy	Cost	Effectiveness	ICER
Vaccine Cost $100	Vaccine Efficacy 75%	100%	Universal	1,287 – 2,021	25.53 – 28.29	Universal Dominates
		100%	Annual	1,685 – 2,385	25.52 – 28.29	Universal Dominates
		75%	Universal	1,286 – 2,021	25.52 – 28.29	Universal Dominates
		75%	Annual	1,648 – 2,353	25.52 – 28.29	Universal Dominates
		50%	Universal	1,286 – 2,019	25.53 – 28.29	Universal Dominates
		50%	Annual	1,613 – 2,319	25.52 – 28.29	Universal Dominates
		25%	Universal	1,286 – 2,022	25.53 – 28.29	Universal Dominates
		25%	Annual	1,581 – 2,283	25.52 – 28.29	Universal Dominates

	Vaccine Efficacy 50%	100%	Universal	1,483 – 2,197	25.53 – 28.29	Universal Dominates
		100%	Annual	1,685 – 2,386	25.52 – 28.29	Universal Dominates
		75%	Universal	1,485 – 2,201	25.53 – 28.29	Universal Dominates
		75%	Annual	1,649 – 2,351	25.53 – 28.29	Universal Dominates
		50%	Universal	1,482 – 2,200	25.52 – 28.29	Universal Dominates
		50%	Annual	1,615 – 2,316	25.52 – 28.29	Universal Dominates
		25%	Universal	1,484 – 2,200	25.52 – 28.29	Universal Dominates
		25%	Annual	1,579 – 2,282	25.52 – 28.29	Universal Dominates

Vaccine Cost $200	Vaccine Efficacy 75%	100%	Universal	1,630 – 2,347	25.53 – 28.29	9,180 – 45,456
		100%	Annual	1,683 – 2,386	25.53 – 28.29	9,180 – 45,456
		75%	Universal	1,649 – 2,348	25.52 – 28.29	1,285 – 31,956
		75%	Annual	1,629 – 2,354	25.53 – 28.29	1,285 – 31,956
		50%	Universal	1,615 – 2,348	25.52 – 28.29	4,222 – 4,755
		50%	Annual	1,616 – 2,378	25.52 – 28.29	4,222 – 4,755
		25%	Universal	1,629 – 2,346	25.53 – 28.30	5,194 – 5,970
		25%	Annual	1,580 – 2,285	25.52 – 28.29	5,194 – 5,970

	Vaccine Efficacy 50%	100%	Universal	1,829 – 2,526	25.53 – 28.29	Annual Dominates
		100%	Annual	1,684 – 2,384	25.53 – 28.29	Annual Dominates
		75%	Universal	1,827 – 2,530	25.52 – 28.29	Annual Dominates
		75%	Annual	1,651 – 2,350	25.52 – 28.29	Annual Dominates
		50%	Universal	1,827 – 2,527	25.52 – 28.29	69,797 – 380,364
		50%	Annual	1,613 – 2,322	25.52 – 28.29	69,797 – 380,364
		25%	Universal	1,827 – 2,527	25.53 – 28.29	59,443 – 74,421
		25%	Annual	1,580 – 2,286	25.52 – 28.28	59,443 – 74,421

Note: Bold ICER values are cost-effective.