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. Author manuscript; available in PMC: 2011 Sep 15.
Published in final edited form as: Pulm Circ. 2011 Jan 1;1(1):48–71. doi: 10.4103/2045-8932.78103

Figure 13.

Figure 13

Inhibitory effect of 4-amynopyridine (4-AP) on macroscopic voltage-gated K+ (Kv) currents (IK(V)) in pulmonary artery smooth muscle cells (PASMC). Rapidly activating and slowly inactivating (a), rapidly activating and non-inactivating (b) and rapidly activating and rapidly inactivating (c) were elicited by step depolarizations between -80 mV and +80 mV from a holding potential of -70 m V. Representative traces are shown before (Cont), during (4-AP) and after (washout) the application of 5 mM 4-AP. I-V curves of 4-AP-sensitive currents (subtraction of the currents recorded during 4-AP from the control currents) are presented in the middle panels for each current type. The 4-AP-sensitive current components depicted to the right were obtained by digital subtraction (Cont − 4-AP)