. Author manuscript; available in PMC: 2011 Sep 15.

Published in final edited form as: Pulm Circ. 2011 Jan 1;1(1):48–71. doi: 10.4103/2045-8932.78103

Table 3. Biophysical properties and molecular identities of voltage-dependent cation channels expressed in human PASMC.

Types of currents	Activation threshold	Blocked by (EC₅₀)	Gene transcripts identified
I_Na	-34 mV	Tetrodotoxin	SCN5A
			SCN6A
I_Ca	-24 mV (HVA)	Nickel	L-type (α_1C, α_1D)
	-50 mV (LVA)	Nifedipine	T-type (α_1G)
			P/Q-type (α_1A)
			N-type (α_1B)
			R-type (α_1E)
			α₂δ₁
			β₁, β₂, β₃, β₄
			γ₆
I_K(V)	-55 mV	4-AP	K_v1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7,
			1-10
			K_v2.1
			K_v3.1, 3.3, 3.4
			K_v4.1, 4.2
			K_v5.1
			K_v6.1, 6.2, 6.3
			K_v9.1, 9.3
			K_v10.1
			K_v11.1
			K_vβ1, β2, β3
I_K(Ca)	-25 mV	Iberiotoxin	Maxi-Kca α₁
		Charybdotoxin	Maxi-Kca β1, β2, β3, β4
			SK2, 3, 4