Table 4.

Molecular targets for therapy in SCC.

Target category	Target	Drug example	Construction	NMSC	HNSCC	ESCC	NSCLC
Growth factor receptor	EGFR	cetuximab/panitumumab	Monoclonal Antibody		●	●	●
		erlotinib/gefitinib	tyrosine kinase inhibitors		●	●	●
	IGF-IR	IGF-IR antibody	Monoclonal Antibody		●		●
	HER3	HER3 antibody	Monoclonal Antibody		●
Signal transduction	mTOR	everolimus	mTOR inhibitor		●		●
	MET	SU11274/PF-02341066	Small molecule		●		●
	Raf/VEGFR	Sorafenib	Small molecule		●		●
	Ras	reovirus	Virus		●[249]
	MEK1/2	AZD6244	Small molecule		●[250]
Angiogenesis	VEGF	bevacizumab	Monoclonal Antibody		●		●
	Raf/VEGFR	Sorafenib	Small molecule		●		●
Cell cycle	CCND1	Flavopiridol	Kinase inhibitor		●	●
Protein degradation	Cox-2	Celecoxib/Meloxicam	Kinase inhibitor	●a		●	●
	Histone deacetylases	vorinostat	HDAC inhibitors				●
Mitosis	Polo-like kinases	BI 2536	PLK1 inhibitor				●[251]
	Aurora Kinase A/B	Aurora Kinase inhibitor	serine/threonine kinases inhibitor		●[252]
Inducers of apoptosis	APO2	AMG655/conatumumab	Monoclonal Antibody		●[253]		●[254]
Cell adhesion molecules	CD44v6	CD44v6 antibody	Monoclonal Antibody		●[230, 255]

^aDiclofence