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. Author manuscript; available in PMC: 2012 Apr 5.
Published in final edited form as: J Neurosci. 2011 Oct 5;31(40):14291–14295. doi: 10.1523/JNEUROSCI.1148-11.2011

Figure 4.

Figure 4

Dendritic Ih is reduced in an in vitro model of SE. A, Representative traces show an evoked seizure-like event in both extracellular and whole-cell current-clamp recordings in the presence of bath solution with 0 Mg2+ and 50 μM bicuculline with extracellular stimulation of perforant path afferents. In the presence of 100 μM glutamate alone, only modest spontaneous excitatory activity is seen. Example traces were not obtained simultaneously. B, In vitro SE conditions for 1 hr caused a significant decrease in dendritic Ih amplitude compared to control, while 100 μM glutamate application for 1 hr had no significant effect.