Figure 4.
Inescapable stress (IS) impairs ipsapirone-mediated inhibition of dorsal raphe nucleus cell firing 24 hr following stress treatment. Groups are expressed as the following: closed squares, homecage control (HC); open circles, IS. Data are expressed as mean percent inhibition ± SEM. IS significantly reduced mean percent inhibition of ipsapirone-mediated inhibition of DRN cell firing as compared to HC (p < 0.001). *Mean ipsapirone-mediated inhibition was significantly different between IS and HC at the 150 and 250 nM doses (p < 0.05).