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. Author manuscript; available in PMC: 2012 Dec 21.
Published in final edited form as: ACS Chem Neurosci. 2011 Dec 21;2(12):730–742. doi: 10.1021/cn200090z

Figure 11.

Figure 11

ML218 reduces rebound burst activity in STN neurons. A. Representative voltage responses (upper) to intracellular injection of hyperpolarizing (−100 pA) followed by depolarizing (+20 pA) current pulses (lower) in control and after application of 3uM ML218 from a current clamp experiment. B. Time course of the number of rebound spikes during the depolarizing current pulse before and after application of 3 uM ML218 from the same cell as in A. a and b indicate the time points at which sample traces were taken. B. Bar graph summarizes the group data showing ML218 reduces the number of rebound spikes in STN neurons (5.7 ± 0.5 spikes/burst with ML218, compared to 16.0 ± 2.8 spikes/burst in control, n = 6, *p < 0.05).