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. Author manuscript; available in PMC: 2012 Oct 21.
Published in final edited form as: J Neurosci. 2011 Nov 16;31(46):16814–16825. doi: 10.1523/JNEUROSCI.3064-11.2011

Figure 5.

Figure 5

Ih in vestibular hair cells of Hcn-deficient mice. Representative traces showing voltage-dependent currents in P8-10 type II mouse utricular hair cells lacking HCN1, 2, or both. Currents were evoked using the same voltage protocol shown in Figure 3. A, Representative traces from a wild-type type II hair cell. B, C, D, Representative traces from an HCN1, HCN2, and HCN1/2-deficient hair cell respectively. Note the complete loss of Ih in both the HCN1 and HCN1/2-deficient cells. Currents recorded from HCN2-deficient hair cells resembled those recorded from wild-type tissue. E, Activation curve from HCN2-deficient hair cells. Data from 8 cells were averaged and fitted with a Boltzmann equation (black line). For comparison, the same Boltzmann curve used to fit the WT data of Fig. 2C is reprinted (red line). F, Summary of maximum conductance for 63 wild-type, 40 HCN1−/−, 8 HCN2−/−, and 8 HCN1/2−/− cells. Asterisks mark statistically significant differences (p<0.001) relative to WT.