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. Author manuscript; available in PMC: 2012 May 9.
Published in final edited form as: J Neurosci. 2011 Nov 9;31(45):16241–16250. doi: 10.1523/JNEUROSCI.3667-11.2011

Figure 4.

Figure 4

CX3CR1 deficiency leads to impairments in LTP. LTP was induced with HFS (2, 1 sec, 100 Hz bursts separated by 20 s; arrow) after 20 min of baseline recording and changes in fEPSP slope are expressed as a percentage of baseline (a). Representative fEPSP traces taken from hippocampal slices of (left to right) wild-type, CX3CR1+/− and CX3CR1−/− mice (b). Both CX3CR1−/− (black) and CX3CR1+/− (red) have deficiencies in LTP of area CA1 compared to wild-type controls (white) (c). The last 5 min of fEPSPs slope recordings were averaged for wild-type (n=12), CX3CR1−/− (n=10) and CX3CR1+/− (n=9) mice (Asterisks represent p<0.05.) (d). Paired-pulse facilitation (PPF) was induced with the use of paired- pulses given with an initial delay of 20 ms and the time to the second pulse was increased 20 ms incrementally until a final delay of 300 ms was reached. There was no significant PPF differences between experimental groups. All data are presented as mean ± S.E p < 0.01