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. Author manuscript; available in PMC: 2012 May 9.
Published in final edited form as: J Neurosci. 2011 Nov 9;31(45):16241–16250. doi: 10.1523/JNEUROSCI.3667-11.2011

Figure 5.

Figure 5

CX3CR1 −/− and CX3CR1+/− show increased hippocampal protein levels of IL-1β compared to littermate wild-type (WT) as measured by ELISA (a). Western blot analysis of hippocampi from wild-type , CX3CR1−/− and CX3CR1+/− mice shows an increase in phospho (p) p-38 protein in CX3CR1−/− and CX3CR1+/− mice compared to that of wild-type (right blot in b; near-infrared image displayed in gray scale). Relative p p-38 expression normalized to β-actin, shows the highest expression in CX3CR1−/− and CX3CR1+/− (b). TNFα cerebellar protein levels are significantly increased in CX3CR1−/− and CX3CR1+/− mice as compared to wild-type mice as measured by ELISA (c). The area of Iba-1 staining is significant higher in CX3CR1−/− when compared to wild-type and CX3CR1+/− as measured by immunohistochemistry (d). Wild-type (WT, white bar), CX3CR1+/− (gray bar), CX3CR1−/− (black bar). Representative photomicrographs of the Iba-1+ cells in the dentate gyrus of wild-type (e) and CX3CR1 deficient mice (f). All data are presented as mean ± SEM p < 0.01. Asterisk represents p < 0.05