Figure 7. Antigen-specific delayed type hypersensitivity (DTH) responses are decreased in mice immunized with Klk6.
DTH responses were determined in Klk6- or CFA-immunized mice at Day 37 post-TMEV infection and in non-infected (TMEV(−)) control mice. DTH responses (ear thickness inches ± s.e.) to challenge with 10 µg of UV-inactivated TMEV or PLP139–151. Significantly less swelling was observed in Klk6-immunized mice relative to CFA-immunized controls at 24 hr post-challenge (ANOVA, P=0.03; *SNK, P<0.05).