TABLE 1. Spinal cord and brain pathology in TMEV-infected mice at 40 and 180 dpi.

Data are expressed as the percentage of spinal cord quadrants showing the pathological abnormality (mean ± standard error).

Group	No. of Mice	Meningeal Inflammation	White Matter Pathology	Total brain Pathology
40d
None	10	19.8 ± 2.4	15.1 ± 1.8	1.13 ± 0.2
CFA	10	21.9 ± 3.1	14.7 ± 2.5	1.14 ± 0.1
OVA	9	24.1 ± 4.3	17.6 ± 3.9	1.13 ± 0.2
Klk6	16	9.8 ± 1.4*	6.5 ± 0.9**	0.55 ± 0.1*
180d
None	13	55.9 ± 10.3	50.9 ± 8.1	1.13 ± 0.1
OVA	12	55.9 ± 7.3	45.9 ± 6.9	1.10 ± 0.1
Klk6	12	56.3 ± 4.1	46.9 ± 4.1	0.97 ± 0.1

Significantly lower pathology scores in mice with Klk6-neutralizing antibodies were observed relative to immunization control groups at 40d but not at 180d post-TMEV infection

^*ANOVA P≤0.006, SNK P<0.05;

^**ANOVA on ranks P=0.002, Dunn’s P<0.05.